CD107a-PB, H4A3, 0.5 mL, ASR

Product No:B13978

The CD107a antigen is the heavily glycosylated 110 kDa lysosomal-associated membrane protein, LAMP-1. Together with LAMP-2, they are the mayor glycoproteins on the membrane of lysosome granules. CD107a molecule is ubiquitously found as intracellular antigen. It is also expressed on the surface of activated platelets, PHA activated, a few monocytic cell lines, and fetal thymus stromal cells. It has been described as a marker of cytotoxic CD8+ Tcell degranulation and of NK cell functional activity. As platelet activation marker, it has characteristics of an adhesive molecule. A minor fraction (<2%) of LAMP-1 is associated with the plasma membrane of most nucleated cells, presumably as a result of selective exchange of lysosomal and plasma membranes. Increased surface expression of LAMP-1 has been observed on transformed cells of high metastatic potential, and on embryonic cells. *Alexa Fluor and Pacific Blue are registered trademarks of Molecular Probes, Inc.

Product Specifications

Target Species Human
Specificity CD107a
Other Names CD107a, LAMP-1, Lysosomal associated membrane protein
Fluorochrome Pacific Blue*
Regulatory Status ASR
Size 0.5 mL
Format Liquid
Flow Product Line IOTest
Clone H4A3
Isotype IgG1 Mouse

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